If confidential or important information is saved on a certain PC that you don`t want anyone accessing, then take a look at EagleEyeOS One 3.0.1. It totally blocks access to CD and DVD drives, Diskettes, Pen Drives, wireless accesses, infrared devices, USB ports, bluetooth, etc.
It thus establishes an access policy through which only a supervisor with the correct password can use those devices. It also saves a history log for all those times users have tried to access blocked areas.